Function and role of regulatory T cells in rheumatoid arthritis

Q Jiang, G Yang, Q Liu, S Wang, D Cui - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with
symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune …

Recent advances in nano-targeting drug delivery systems for rheumatoid arthritis treatment

H Li, R Gou, J Liao, Y Wang, R Qu, Q Tang… - Acta Materia …, 2023 - scienceopen.com
Rheumatoid arthritis is a systemic inflammatory disease that can lead to articular cartilage
destruction and periarticular bone erosion, thus ultimately compromising joint integrity and …

Biomimetic and bioinspired intervention strategies for the treatment of rheumatoid arthritis

Y Han, X Pang, G Pi - Advanced Functional Materials, 2021 - Wiley Online Library
Rheumatoid arthritis (RA) affects the joints and extra‐articular organs and poses a
significant health care problem in the modern era. Although current standard treatment …

Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing

R Vlashi, X Zhang, H Li, G Chen - Reviews in Endocrine and Metabolic …, 2024 - Springer
Osteoarthritis (OA) is an incapacitating and one of the most common physically degenerative
conditions with an assorted etiology and a highly complicated molecular mechanism that to …

Effect of interleukin-6,-17,-21,-22, and-23 and STAT3 on signal transduction pathways and their inhibition in autoimmune arthritis

I Woś, J Tabarkiewicz - Immunologic Research, 2021 - Springer
Rheumatic diseases are complex autoimmune diseases which include among others
rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and psoriatic arthritis (PsA) …

New treatment for osteoarthritis: Gene therapy

X Li, L Shen, Z Deng, Z Huang - Precision Clinical Medicine, 2023 - academic.oup.com
Osteoarthritis is a complex degenerative disease that affects the entire joint tissue. Currently,
non-surgical treatments for osteoarthritis focus on relieving pain. While end-stage …

Intra-articular delivery of AAV vectors encoding PD-L1 attenuates joint inflammation and tissue damage in a mouse model of rheumatoid arthritis

W Li, J Sun, SL Feng, F Wang, MZ Miao… - Frontiers in …, 2023 - frontiersin.org
Objective Rheumatoid arthritis (RA) is the most common form of autoimmune inflammatory
arthritis. Intra-articular gene delivery to block proinflammatory cytokines has been studied in …

COVID-19 immunotherapy: Treatment based on the immune cell-mediated approaches

M Zavvar, A Yahyapoor, H Baghdadi… - International …, 2022 - Elsevier
Multiple efforts are currently underway to control and treat severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19) …

Intra-articular delivery of an AAV-anti-TNF-α vector alleviates the progress of arthritis in a RA mouse model

X Ke, Q Xie, S Luo, Q Li, Q Zheng, Z Zhang - Human Gene Therapy, 2024 - liebertpub.com
Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease marked by joint
destruction and functional impairment. Tumor necrosis factor (TNF) plays a critical role in RA …

Advancements in extracellular vesicle targeted therapies for rheumatoid arthritis: insights into cellular origins, current perspectives, and emerging challenges

MT Jouybari, F Mojtahedi, M Babaahmadi… - Stem Cell Research & …, 2024 - Springer
Rheumatoid arthritis (RA) remains a challenging chronic autoimmune disorder
characterized by persistent joint inflammation and damage. While modern regenerative …