In adapting to the intracellular niche, obligate intracellular bacteria usually undergo a
reduction of genome size by eliminating genes not needed for intracellular survival. These …

Autophagy is a vital conserved degradative process that maintains cellular homeostasis by
recycling or eliminating dysfunctional cellular organelles and proteins. More recently …

Scrub typhus, caused by Orientia tsutsugamushi, is a serious public health problem in the
Asia-Pacific region, threatening the health of more than one billion people. China is one of …

Climate is one of the major factors determining the prevalence and seasonality of vector
borne diseases like scrub typhus (ST). We analyzed, the association of the meteorological …

Scrub typhus is a life-threatening zoonosis caused by the obligate intracellular bacterium
Orientia tsutsugamushi (Ot) that is transmitted by the infected larvae of trombiculid mites …

Background Large-scale outbreaks of scrub typhus combined with its emergence in new
areas as a vector-borne rickettsiosis highlight the ongoing neglect of this disease. This study …

During evolution Orientia tsutsugamushi became a smarter obligate bacterium to establish
as intracellular pathogens. O. tsutsugamushi is a human pathogenic bacterium responsible …

Scrub typhus infections caused by Orientiatsutsugamushi (OT), continue to remain
underdiagnosed globally, due to the lack of distinctive symptoms. The elusive nature of the …

Orientia tsutsugamushi is an obligate intracellular bacterium that causes scrub typhus, a
potentially fatal rickettsiosis, and for which no genetic tools exist. Critical to addressing this …

Orientia tsutsugamushi is a genetically intractable obligate intracellular bacterium, causes
scrub typhus, and has one of the largest known armamentariums of ankyrin repeat …