Conspectus Compounds containing a difluoromethylene unit have gained increasing
attention due to their utility in drug design. Classic methods for the synthesis of these …

Transition-metal-mediated fluoroalkylation is a hot research topic in current organofluorine
chemistry. In the past five years, due to the development of new perfluoroalkylation reagents …

A new olefination protocol for transition-metal-free cross-coupling of two carbene fragments
arising from two different sources, namely, a nonfluorinated carbene fragment resulting from …

Organic systems still dominate several traditional areas of chemical science and well-known
applications, such as the synthesis of pharmaceutical compounds and drugs. However, a …

The mechanism of CF2 transfer from TMSCF3 (1), mediated by TBAT (2–12 mol%) or by NaI
(5–20 mol%), has been investigated by in situ/stopped-flow 19F NMR spectroscopic …

A facile one-pot approach for the azidodifluoromethylation of aldehydes via in situ-
generated azidodifluoromethenide (N3CF2–) utilizing commercially available TMSCF2Br …

This report describes a three-component, Ni-catalyzed reductive coupling that enables the
convergent synthesis of tertiary benzhydryl amines, which are challenging to access by …

An efficient method for the selective C‐difluoromethylation of carbon acids with the reagent
TMSCF2Br has been developed. A variety of structurally diverse sp3‐and sp‐hybridized …

gem-Difluorinated phosphonium salts, which are readily obtained from aldehydes and
difluoromethylene phosphobetaine, can serve as a source of radicals under reductive …

A method for nucleophilic difluoromethylation of reactive Michael acceptors, aldehydes, and
azomethines is described. The reaction is performed using the readily available and air …