Upon activation, platelets secrete more than 300 active substances from their intracellular
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …

Metastasis accounts for 90% of breast cancer mortality. Despite the significant progress
made over the past decade in cancer medicine our understanding of metastasis remains …

Breast cancer is a multifactorial disease and driven by aberrant regulation of cell signaling
pathways due to the acquisition of genetic and epigenetic changes. An array of growth …

Inflammatory breast cancer (IBC) is a rare and aggressive disease that accounts for~ 2–4%
of all breast cancers. However, despite its low incidence rate, IBC is responsible for 7–10 …

Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important
functions in the regulation of growth and survival of certain cell types during embryonal …

Cancer-associated fibroblasts (CAFs) are highly prominent in breast tumors, but their
functional heterogeneity and origin are still largely unresolved. We report that bone marrow …

The tumor microenvironment (TME) is an intricate system within solid neoplasms. In this
review, we aim to provide an updated insight into the TME with a focus on the effects of …

Triple-negative breast cancers (TNBCs) constitute a heterogeneous subtype of breast
cancers that have a poor clinical outcome. Although no approved targeted therapy is …

Cancer dependency maps have accelerated the discovery of tumor vulnerabilities that can
be exploited as drug targets when translatable to patients. The Cancer Genome Atlas …

Organ-specific metastasis is the primary cause of cancer patient death. The distant
metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of …