While the root causes for individual neurodegenerative diseases are distinct, many shared
pathological features and mechanisms contribute to neurodegeneration across diseases …

MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal
differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis …

Parkinson's disease (PD) is the most prevalent central nervous system (CNS) movement
disorder and the second most common neurodegenerative disease overall. PD is …

To investigate the role of microRNAs in regulating oligodendrocyte (OL) differentiation and
myelination, we utilized transgenic mice in which microRNA processing was disrupted in OL …

Abstract β-catenin is a multi-functional protein that has an important role in the mature
central nervous system; its dysfunction has been implicated in several neuropsychiatric …

Brain development crucially depends on the integrity of microRNA (miRNA) pathways, which
function at the post-transcriptional level as a rheostat of the transcriptome and proteome of …

Rationale: Heart failure is a deadly and devastating disease that places immense costs on
an aging society. To develop therapies aimed at rescuing the failing heart, it is important to …

Defective RNA metabolism is an emerging mechanism involved in ALS pathogenesis and
possibly in other neurodegenerative disorders. Here, we show that microRNA (miRNA) …

To investigate the role of Dicer and microRNAs in the mammalian CNS, we used mice in
which the second RNase III domain of Dicer was conditionally floxed. Conditional Dicer mice …