Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptor, displays
a fast antidepressant activity in treatment-resistant depression and in rodent models of …

The role of serotonin in major depressive disorder (MDD) is the focus of accumulating
clinical and preclinical research. The results of these studies reflect the complexity of …

Due to the fish-specific genome duplication event (~ 320–350 mya), some genes which
code for serotonin proteins were duplicated in teleosts; this duplication event was preceded …

Major depressive disorder (MDD) is the leading cause of disability worldwide. The serotonin
hypothesis may be the model of MDD pathophysiology with the most support. The majority of …

Understanding the neurobiological underpinnings of depressive disorder constitutes a
pressing challenge in the fields of psychiatry and neurobiology. Depression represents one …

Independent from homeostatic needs, the consumption of foods originating from
hyperpalatable diets is defined as hedonic eating. Hedonic eating can be observed in many …

Background The activation of endoplasmic reticulum (ER) stress is an early pathological
hallmark of Alzheimer's disease (AD) brain, but how ER stress contributes to the onset and …

Objective The study aimed to determine the effect of electroacupuncture (EA) on Wistar
Kyoto (WKY) depressive model rats and explore the possible mechanism of EA on …

Modulation of neurotransmission by the monoamines dopamine (DA), norepinephrine (NE),
and serotonin (5-HT) is critical for normal nervous system function. Precise temporal and …

The effects of serotonin (5-HT) on anxiety and depression are mediated by a number of 5-HT
receptors, including autoreceptors that act to inhibit 5-HT release. While the majority of …