For several decades, few substantial therapeutic advances have been made for patients
with acute myeloid leukaemia. However, since 2017 unprecedented growth has been seen …

MYB transcription factors are highly conserved from plants to vertebrates, indicating that
their functions embrace fundamental mechanisms in the biology of cells and organisms. In …

Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. In the past
ALL was intractable but now the survival probability is as high as 80–90%. Improved …

MicroRNAs (miRNAs) are a widely-studied class of non-coding RNAs characterized by their
short length (18-25 nucleotides). The precise functions of miRNAs are not well-elucidated; …

Background Current cancer mortality statistics are important for public health decision-
making and resource allocation. Age-standardized rates and numbers of deaths are …

Acute myeloid leukemia (AML) is a heterogeneous group of diseases, whose classification
is based on lineage-commitment and genetics. Although rare in childhood, it is the most …

All-Trans Retinoic Acid (ATRA) is the most active metabolite of vitamin A. It is critically
involved in the regulation of multiple processes, such as cell differentiation and apoptosis …

Graft-versus-host disease (GVHD) occasionally leads to morbidity and mortality but is
thought to reduce the risk of relapses in patients with a hematological malignancy. However …

Recently, we demonstrated that sterile α motif and HD domain containing protein 1
(SAMHD1) is a major barrier in acute myelogenous leukemia (AML) cells to the cytotoxicity …

Acute myeloid leukemia (AML) is a heterogeneous disease with a genetic, epigenetic, and
transcriptional etiology mainly presenting somatic and germline abnormalities. AML …