Metabolomics in cancer research and emerging applications in clinical oncology

DR Schmidt, R Patel, DG Kirsch… - CA: a cancer journal …, 2021 - Wiley Online Library
Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Metabolomics for laboratory diagnostics

R Bujak, W Struck-Lewicka, MJ Markuszewski… - … of pharmaceutical and …, 2015 - Elsevier
Metabolomics is an emerging approach in a systems biology field. Due to continuous
development in advanced analytical techniques and in bioinformatics, metabolomics has …

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

D Kim, BP Fiske, K Birsoy, E Freinkman, K Kami… - Nature, 2015 - nature.com
Cancer cells adapt their metabolic processes to support rapid proliferation, but less is known
about how cancer cells alter metabolism to promote cell survival in a poorly vascularized …

Method validation strategies involved in non-targeted metabolomics

S Naz, M Vallejo, A García, C Barbas - Journal of Chromatography A, 2014 - Elsevier
Non-targeted metabolomics is the hypothesis generating, global unbiased analysis of all the
small-molecule metabolites present within a biological system, under a given set of …

Oncogene-selective sensitivity to synchronous cell death following modulation of the amino acid nutrient cystine

I Poursaitidis, X Wang, T Crighton, C Labuschagne… - Cell reports, 2017 - cell.com
Cancer cells reprogram their metabolism, altering both uptake and utilization of extracellular
nutrients. We individually depleted amino acid nutrients from isogenic cells expressing …

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

S Kon, K Ishibashi, H Katoh, S Kitamoto, T Shirai… - Nature cell …, 2017 - nature.com
Recent studies have revealed that newly emerging transformed cells are often apically
extruded from epithelial tissues. During this process, normal epithelial cells can recognize …

Signaling through the phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) axis is responsible for aerobic glycolysis mediated by glucose …

H Makinoshima, M Takita, K Saruwatari… - Journal of Biological …, 2015 - ASBMB
Oncogenic epidermal growth factor receptor (EGFR) signaling plays an important role in
regulating global metabolic pathways, including aerobic glycolysis, the pentose phosphate …

Primordial aqueous alteration recorded in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu

Y Takano, H Naraoka, JP Dworkin, T Koga… - Nature …, 2024 - nature.com
We report primordial aqueous alteration signatures in water-soluble organic molecules from
the carbonaceous asteroid (162173) Ryugu by the Hayabusa2 spacecraft of JAXA. Newly …

Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma

H Makinoshima, M Takita, S Matsumoto… - Journal of Biological …, 2014 - ASBMB
Genetic mutations in tumor cells cause several unique metabolic phenotypes that are critical
for cancer cell proliferation. Mutations in the tyrosine kinase epidermal growth factor receptor …

Biomarkers in prostate cancer: what's new?

DA Sartori, DW Chan - Current opinion in oncology, 2014 - journals.lww.com
Several new tests, as discussed in this review, have become available during the last 2
years. Although the intended use of most of these tests is to distinguish PCa from benign …