Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell
death and survival, playing a pivotal role in multiple interconnected cell signaling …

The plasmalogens are a class of glycerophospholipids which contain a vinyl-ether and an
ester bond at the sn-1 and sn-2 positions, respectively, in the glycerol backbone. They …

Modulation of membrane lipid composition and organization is currently developing as an
effective therapeutic strategy against a wide range of diseases, including cancer. This field …

For many decades classical anti-tumor therapies included chemotherapy, radiation and
surgery; however, in the last two decades, following the identification of the genomic drivers …

Cancer is a multi-process disease where different mechanisms exist in parallel to ensure
cell survival and constant adaptation to the extracellular environment. To adapt rapidly …

Our current understanding of membrane lipid composition, structure and functions has led to
the investigation of their role in cell signaling, both in healthy and pathological cells. As a …

Trypanosomiases and leishmaniases are neglected tropical diseases that have been
spreading to previously non-affected areas in recent years. Identification of new …

Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer
death among men worldwide. While the five-year survival in local and regional prostate …

Abstract Edelfosine (EDL) and Fulvestrant (FUL), proven anticancer agents, suffer significant
limitations for low water solubility and poor bioavailability. FUL is an effective breast cancer …