Objective–To briefly describe the history of and available data on anti‐calcitonin gene‐
related peptide (CGRP) therapies for headache. Background–CGRP was proposed as a …

Background Migraine is a disabling and chronic neurovascular headache disorder.
Trigeminal vascular activation and release of calcitonin gene-related peptide (CGRP) play a …

The existence of the neural control of mast cell functions has long been proposed. Mast cells
(MCs) are localized in association with the peripheral nervous system (PNS) and the brain …

The CGRP system has emerged as a key pharmacological target for the treatment of
migraine. However, some individuals who suffer from migraine have low or no response to …

ABSTRACT Introduction Calcitonin Gene-Related Peptide (CGRP) has gradually emerged
as a suitable therapeutic target to treat migraine. Considering the social and economic …

Migraine is a primary headache disorder which has complex neurogenic pathophysiological
mechanisms still requiring full elucidation. The sensory nerves and meningeal mast cell …

Background and Purpose Dioscin has multiple biological activities and is beneficial for
cardiovascular and cerebral vascular diseases. Here, we investigated the protective effects …

Neurogenic inflammation including calcitonin gene-related peptide (CGRP) and substance-
P (SP) release plays a pivotal role in migraine pathogenesis. Prevalence of migraine is~ 3 …

Osteoporosis, a metabolic bone disorder characterized by decreased bone mass per unit
volume, poses a significant global health burden due to its association with heightened …

SARS-CoV-2 (COVID-19) leads to severe acute respiratory syndrome by settling the
pulmonary system. Mast cells (MCs) are multifunctional immune cells that are extensively …