Simple Summary Skeletal muscle mass is an important economic trait, and muscle
development and growth is a crucial factor to supply enough meat for human consumption …

Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …

Skeletal muscle hypertrophy is defined as an increase in muscle mass, which in the adult
animal comes as a result of an increase in the size, as opposed to the number, of pre …

The formation of skeletal muscle is a tightly regulated process that is critically modulated by
Wnt signaling. Myogenesis is dependent on the precise and dynamic integration of multiple …

Stem cells are rare cells that are uniquely capable of both reproducing themselves (self-
renewing) and generating the differentiated cell types that are needed to carry out …

Satellite cells in skeletal muscle are a heterogeneous population of stem cells and
committed progenitors. We found that quiescent satellite stem cells expressed the Wnt …

Adult skeletal muscle possesses extraordinary regeneration capacities. After muscle injury
or exercise, large numbers of newly formed muscle fibers are generated within a week as a …

Wnt is a family of signaling molecules involved in embryogenesis, adult tissue repair, and
cancer. They activate canonical and noncanonical Wnt signaling cascades in target cells …

Wnt7a signals through its receptor Fzd7 to activate the planar-cell-polarity pathway and
drive the symmetric expansion of satellite stem cells resulting in enhanced repair of skeletal …

Myoblast fusion is a critical process that contributes to the growth of muscle during
development and to the regeneration of myofibers upon injury. Myoblasts fuse with each …