Increasing development costs and higher failure rate in clinical trials has reduced the
repertoire of newer drugs in the market for clinical use. The most appropriate approach to …

Cancer is a very risky life-threatening disease having most formidable afflictions in the world.
Several anticancer agents are commercially accessible, however, the emergence of …

Ciprofloxacin (CIP) has been listed in the last version of the surface water due to its ability to
kill human cells by inhibiting the activity of DNA topoisomerase IV. Thus, CIP, along with …

Importance Fluoroquinolones are among the most commonly prescribed antibiotics. Recent
clinical studies indicated an association between fluoroquinolone use and increased risk of …

Different studies about the anticancer potential of several medically used antibacterial
fluoroquinolones have been established. Fluoroquinolone derivatives, like some anti …

Fluoroquinolones represent an interesting synthetic class of antimicrobial agents with broad
spectrum and potent activity. Since the discovery of nalidixic acid, the prototype of …

Topoisomerase IIα (topoIIα) is an essential mammalian enzyme that topologically modifies
DNA and is required for chromosome segregation during mitosis. Previous research …

The design, synthesis and identification of a novel series of Mannich bases of ciprofloxacin
was reported. Naphthol derivatives 2a and 2b showed highly potent cytotoxic activity among …

Fluoroquinolones (FQs), commonly known for their antibiotic properties, exhibit additional
pharmacological potential with anti-proliferative effects on various malignant cell types and …

In this paper we present a first insight into the cytotoxic action mode of copper (I) iodide or
copper (I) thiocyanate complexes with a phosphine derivative of sparfloxacin (a 3rd …