Quinoline hybrids and their antiplasmodial and antimalarial activities
YQ Hu, C Gao, S Zhang, L Xu, Z Xu, LS Feng… - European Journal of …, 2017 - Elsevier
Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …
parasite species, responsible for nearly one million deaths every year), is one of the most …
Quinolines and structurally related heterocycles as antimalarials
The quinoline scaffold is prevalent in a variety of pharmacologically active synthetic and
natural compounds. The discovery of chloroquine, the most famous drug containing this …
natural compounds. The discovery of chloroquine, the most famous drug containing this …
Primaquine revisited six decades after its discovery
Primaquine was firstly synthesized in 1946 in the USA, and is the most representative
member of the anti-malarial 8-aminoquinolines. Six decades have passed and primaquine …
member of the anti-malarial 8-aminoquinolines. Six decades have passed and primaquine …
Recent developments in the design and synthesis of hybrid molecules basedon aminoquinoline ring and their antiplasmodial evaluation
VV Kouznetsov, A Gómez-Barrio - European journal of medicinal chemistry, 2009 - Elsevier
A short history of hybrid molecules based on aminoquinolines gave interesting and
important information useful for organic and medicinal chemistry, which are deeply involved …
important information useful for organic and medicinal chemistry, which are deeply involved …
Recent advances in antimalarial drug development
Malaria caused by protozoa of the genus Plasmodium, because of its prevalence, virulence,
and drug resistance, is the most serious and widespread parasitic disease encountered by …
and drug resistance, is the most serious and widespread parasitic disease encountered by …
Ring-substituted quinolines as potential anti-tuberculosis agents
We report in vitro antimycobacterial properties of ring-substituted quinolines (series 1–4)
constituting 56 analogues against drug-sensitive and drug-resistant M. tuberculosis H37Rv …
constituting 56 analogues against drug-sensitive and drug-resistant M. tuberculosis H37Rv …
Theoretical insights into the anti-SARS-CoV-2 activity of chloroquine and its analogs and in silico screening of main protease inhibitors
AS Achutha, VL Pushpa, S Suchitra - Journal of proteome …, 2020 - ACS Publications
Corona virus disease (COVID-19) is a dangerous disease rapidly spreading all over the
world today. Currently there are no treatment options for it. Drug repurposing studies …
world today. Currently there are no treatment options for it. Drug repurposing studies …
Synthesis, antimalarial, antileishmanial, and antimicrobial activities of some 8-quinolinamine analogues
M Jain, SI Khan, BL Tekwani, MR Jacob… - Bioorganic & medicinal …, 2005 - Elsevier
In the present communication, newly synthesized 8-quinolinamines (25–27) related to
previously reported 2-tert-butylprimaquine (2) were evaluated for their in vitro antimalarial …
previously reported 2-tert-butylprimaquine (2) were evaluated for their in vitro antimalarial …
Synthesis, antiprotozoal, antimicrobial, β-hematin inhibition, cytotoxicity and methemoglobin (MetHb) formation activities of bis (8-aminoquinolines)
In continuing our search of potent antimalarials based on 8-aminoquinoline structural
framework, three series of novel bis (8-aminoquinolines) using convenient one to four steps …
framework, three series of novel bis (8-aminoquinolines) using convenient one to four steps …
Design, synthesis and evaluation of antimalarial potential of polyphosphazene linked combination therapy of primaquine and dihydroartemisinin
S Kumar, RK Singh, R Sharma, RSR Murthy… - European Journal of …, 2015 - Elsevier
Abstract Various polymer drug conjugates (13–16) such as primaquine and
dihydroartemisinin conjugated 2-propoxy substituted polyphosphazenes (13), primaquine …
dihydroartemisinin conjugated 2-propoxy substituted polyphosphazenes (13), primaquine …