Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved
in the regulation of fundamental cellular processes, including transcription, RNA processing …

Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

Arginine methylation is a common post-translational modification functioning as an
epigenetic regulator of transcription and playing key roles in pre-mRNA splicing, DNA …

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

Small ubiquitin-like modifiers (SUMOs) are post-translational modifications (PTMs) that
regulate nuclear cellular processes. Here we used an augmented K0–SUMO proteomics …

Numerous substrates have been identified for Type I and II arginine methyltransferases
(PRMTs). However, the full substrate spectrum of the only type III PRMT, PRMT7, and its …

Genome-wide association studies (GWAS) have identified the PICALM (Phosphatidylinositol
binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus …

Exercise induces signaling networks to improve muscle function and confer health benefits.
To identify divergent and common signaling networks during and after different exercise …

Cells must be able to cope with the challenge of folding newly synthesized proteins and
refolding those that have become misfolded in the context of a crowded cytosol. One such …