Despite advances in neurosurgery, chemotherapy and radiotherapy, glioblastoma remains
one of the most treatment-resistant CNS malignancies, and the tumour inevitably recurs. The …

Mesenchymal stem/stromal cells (MSCs) are multipotent cells that are emerging as the most
promising means of allogeneic cell therapy. MSCs have inherent immunomodulatory …

The immune system plays key roles in tissue homeostatic and disease processes, and
manipulation of innate and adaptive immune responses is of great promise for a wide array …

The administration of inactivated tumor cells is known to induce a potent antitumor immune
response; however, the efficacy of such an approach is limited by its inability to kill tumor …

Mesenchymal stem cells (MSCs) are regarded as highly promising cells for allogeneic cell
therapy, owing to their multipotent nature and ability to display potent and varied functions in …

Intratumor spatial heterogeneity facilitates therapeutic resistance in glioblastoma (GBM).
Nonetheless, understanding of GBM heterogeneity is largely limited to the surgically …

Glioblastomas (GBM) are the most frequent and aggressive malignant primary brain tumor
and remains a therapeutic challenge: even after multimodal therapy, median survival of …

Glioblastoma (GBM) is a particularly aggressive brain cancer associated with high
recurrence and poor prognosis. The standard of care, surgical resection followed by …

Importance The gut microbiome, home to the vast kingdom of diverse commensal bacteria
and other microorganisms residing within the gut, was once thought to only have roles …

Surgical resection is the main treatment option for most solid tumors, yet cancer recurrence
after surgical resection remains a significant challenge in cancer therapy. Recent advances …