Microbial cells have been widely used in the industry to obtain various biochemical
products, and evolutionary engineering is a common method in biological research to …

Quorum sensing (QS)-based dynamic regulation has been widely used as basic tool for fine-
tuning gene expression in response to cell density changes without adding expensive …

Microbial cell factories have been used for the production of valuable chemical compounds
using a classical metabolic engineering approach, but this requires much time and cost, and …

Pyruvate is a central metabolite for the biological production of various chemicals. In
eukaryotes, pyruvate produced by glycolysis is used in conversion to ethanol and lactate …

Klebsiella oxytoca naturally produces a large amount of 2, 3-butanediol (2, 3-BD), a
promising bulk chemical with wide industrial applications, along with various byproducts. In …

Background Recent advancements in omics measurement technologies have led to an ever-
increasing amount of available experimental data that necessitate systems-oriented …

Laboratory evolution provides phenotype–genotype mappings and quantitative analysis of
selective pressures, giving important insights about evolutionary dynamics. Moreover …

The incompleteness of genome-scale metabolic models is a major bottleneck for systems
biology approaches, which are based on large numbers of metabolites as identified and …

Corynebacterium glutamicum, a high GC content gram-positive soil bacterium in
Actinobacteria, has been used for the industrial production of amino acids and engineered …

Integrated assessment studies are beginning to take place in both developed and
developing countries. Initial frameworks for understanding sustainable systems exist. The …