Calorie restriction (CR), the reduction of dietary intake below energy requirements while
maintaining optimal nutrition, is the only known nutritional intervention with the potential to …

The epithelial sodium channel (ENaC) is composed of three homologous subunits and
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …

GTF (Gene Transfer Format) and GFF (General Feature Format) are popular file formats
used by bioinformatics programs to represent and exchange information about various …

Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-
related disorders in most species but its impact in nonhuman primates has been …

Long-lasting, latently infected resting CD4+ T cells are the greatest obstacle to obtaining a
cure for HIV infection, as these cells can persist despite decades of treatment with …

Since its 2001 debut, the University of California, Santa Cruz (UCSC) Genome Browser
(http://genome. ucsc. edu/) team has provided continuous support to the international …

Despite widespread use of the bacille Calmette–Guérin (BCG) vaccine, tuberculosis (TB)
remains a leading cause of global mortality from a single infectious agent (Mycobacterium …

Social status is one of the strongest predictors of human disease risk and mortality, and it
also influences Darwinian fitness in social mammals more generally. To understand the …

Comprehensive knowledge of immunoglobulin genetics is required to advance our
understanding of B cell biology. Validated immunoglobulin variable (V) gene databases are …

Aging as a research pursuit is fairly new compared with traditional lines of medical research.
A growing field of investigators is focused on understanding how changes in tissue biology …