Histone dacetylases (HDACs) are a group of enzymes that remove acetyl groups from
histones and regulate expression of tumor suppressor genes. They are implicated in many …

The epigenetic abnormality is generally accepted as the key to cancer initiation. Epigenetics
that ensure the somatic inheritance of differentiated state is defined as a crucial factor …

Abstract Among different Histone deacetylases (HDACs), histone deacetylase 3 (HDAC3) is
an epigenetic drug target which is currently marked as a potential therapeutic strategy to …

Histone Deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that
play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis …

Initial studies of cancer metabolism in the early 1920s found that cancer cells were
phenotypically characterized by aerobic glycolysis, in that these cells favor glucose uptake …

The histone deacetylases (HDACs) enzymes provided crucial role in transcriptional
regulation of cells through deacetylation of nuclear histone proteins. Discoveries related to …

Accumulating epidemiological evidence shows that obesity is associated with an increased
risk of several types of adult cancers, including endometrial cancer. Chronic …

Among the epigenetic changes, histone acetylation has been recognized as a fundamental
process that strongly affects gene expression regulation. Disrupt of this phenomenon has …

Exercise can enhance learning and memory and produce resistance against stress-related
psychiatric disorders such as depression and anxiety. In rats, these beneficial effects of …

Hypoxia inducible factor 1α (HIF-1α) is a master regulator of tumor angiogenesis being one
of the major targets for cancer therapy. Previous studies have shown that Histone …