LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases
and the only two members of the LIM kinase family. They play a crucial role in the regulation …

Highlights•Existing models for drug discovery and development against glioblastoma
multiforme (GBM) have limitations.•We review advances in 3D systems that promise more …

While extracellular matrix (ECM) mechanics strongly regulate stem cell commitment, the
field's mechanistic understanding of this phenomenon largely derives from simplified two …

Abstract LIM kinase 1 (LIMK1) is a member of the LIMK family that has been considered to
be involved in chemoresistance in various tumors, and N 6-methyladenosine (m 6 A) is the …

Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV
astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain …

Background Protein-coding gene LIM Domain Kinase 1 (LIMK1) is upregulated in various
tumors and reported to promote tumor invasion and metastasis. However, the prognostic …

Simple Summary Prostate cancer is the principal cause of cancer-related mortality in men.
While localized tumors can be successfully treated by orchiectomy or medical castration …

Simple Summary Anaplastic thyroid carcinoma (ATC) is a biological aggressive human
carcinoma and causes most of the thyroid cancer related deaths. Non-protein producing …

Glioblastoma (GBM) is the most common primary malignant cancer of the central nervous
system. Insufficient oxygenation (hypoxia) has been linked to GBM invasion and aggression …

Cofilin, as a depolymerization factor of actin filaments, has been widely studied. Evidences
show that cofilin has a role in actin structural reorganization and dynamic regulation. In …