Neurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and
mutations. Their clinical symptoms are different. However, individuals with NDDs have …

Background Individuals affected with autism often suffer additional co-morbidities such as
intellectual disability. The genes contributing to autism cluster on a relatively limited number …

De novo heterozygous mutations in activity-dependent neuroprotective protein (ADNP)
cause autistic ADNP syndrome. ADNP mutations impair microtubule (MT) function, essential …

Severe speech disorders lead to poor literacy, reduced academic attainment and negative
psychosocial outcomes. As early as the 1950s, the familial nature of speech disorders was …

ADNP syndrome, involving the ADNP transcription factor of the SWI/SNF chromatin-
remodeling complex, is characterized by developmental delay, intellectual disability, and …

Identification of factors that regulate chromatin condensation is important for understanding
of gene regulation. High-mobility group AT-hook (HMGA) proteins 1 and 2 are abundant …

(1) Background: Recently, we showed aberrant nuclear/cytoplasmic boundaries/activity-
dependent neuroprotective protein (ADNP) distribution in ADNP-mutated cells. This …

O-GlcNAc transferase (OGT) is the sole enzyme responsible for the post-translational
modification O-GlcNAc on thousands of target nucleocytoplasmic proteins. To date, nine …

Background The POGZ gene has been found frequently mutated in neurodevelopmental
disorders (NDDs), particularly autism spectrum disorder (ASD) and intellectual disability (ID) …

Although chromatin remodelers are among the most important risk genes associated with
neurodevelopmental disorders (NDDs), the roles of these complexes during brain …