Ischemia-reperfusion injury is associated with serious clinical manifestations, including
myocardial hibernation, acute heart failure, cerebral dysfunction, gastrointestinal …

Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

Oxidative stress is a common denominator in the pathology of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …

Acute and chronic excessive intracellular increase of reactive oxygen species (ROS) is
involved in the development and progression of cardiovascular diseases. ROS are by …

Accumulating evidence indicatesthat programmed necrosis plays a critical role in cell death
during ischemia–reperfusion. Necrostatin-1 (Nec-1), a small molecule capable of inhibiting a …

We have previously shown that mesenchymal stem cells (MSC) improve function upon
integration in ischemic myocardium. We examined whether specific cytokines and growth …

Flavonoids have long been acknowledged for their unique antioxidant properties, and
possess other activities that may be relevant to heart ischemia–reperfusion. They may …

Fluorene is an important toxic chemical that exists ubiquitously in the environment, and it
has also been suggested to exert potential deleterious effects on soil invertebrates …

Ischemia/reperfusion injury (IRI) is crucial in the pathology of major cardiovascular diseases,
such as stroke and myocardial infarction. Paradoxically, both the lack of oxygen during …

Mitochondria play a critical role in cardiac function, and are also increasingly recognized as
end effectors for various cardioprotective signaling pathways. Mitochondria use oxygen as a …