Organization and development of the early vertebrate hindbrain are controlled by a cascade
of regulatory interactions that govern the process of segmentation and patterning along the …

Currently, the dynamic accessible elements that determine regulatory programs responsible
for the unique identity and function of each cell type during zebrafish embryogenesis lack …

Cardiogenic growth factors play important roles in heart development. Placental growth
factor (PLGF) has previously been reported to have angiogenic effects; however, its potential …

The activation of sp5 in response to Wnt/β-catenin signaling is observed in many species
during axis patterning, neural crest induction, maintenance and differentiation of stem cells …

The vertebrate eye originates from the eye field, a domain of cells specified by a small
number of transcription factors. In this study, we show that Tcf7l1a is one such transcription …

Smad2 and Smad3, two essential nuclear effectors of transforming growth factor (Tgf)-β
signals, have been found to be implicated in mesoderm and endoderm development in …

Although many components of the genetic pathways that provide positional information
during embryogenesis have been identified, it remains unclear how these signals are …

Wnt/β-catenin signaling controls various cell fates in metazoan development, and its
dysregulation is often associated with cancer formation. However, regulations of this …

The Sp family of transcription factors is required for the expression of cell cycle-and
developmentally regulated genes, and the deregulated expression of a handful of family …

Piwi (P-element-induced wimpy testis) proteins have been shown to play important roles in
maintenance of germ line stem cells, germ cell proliferation and differentiation, and control of …