Antibiotic hybrids: the next generation of agents and adjuvants against Gram-negative pathogens?
The global incidence of drug-resistant Gram-negative bacillary infections has been
increasing, and there is a dire need to develop novel strategies to overcome this problem …
increasing, and there is a dire need to develop novel strategies to overcome this problem …
Iron acquisition systems of gram-negative bacterial pathogens define TonB-dependent pathways to novel antibiotics
Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …
natural competition for the metal between bacterial pathogens and their human or animal …
[PDF][PDF] Iron acquisition and its control in Pseudomonas aeruginosa: many roads lead to Rome
K Poole, GA McKay - Front Biosci, 2003 - researchgate.net
[Frontiers in Bioscience 8, d661-686, May 1, 2003] 661 IRON ACQUISITION AND ITS CONTROL
IN PSEUDOMONAS AERUGINOSA: MANY ROADS LE Page 1 [Frontiers in Bioscience 8 …
IN PSEUDOMONAS AERUGINOSA: MANY ROADS LE Page 1 [Frontiers in Bioscience 8 …
Exploiting bacterial iron acquisition: siderophore conjugates
Siderophores are chelators synthesized by bacteria and fungi to sequester iron, which is
essential for virulence and pathogenicity. Since the process involves active transport, which …
essential for virulence and pathogenicity. Since the process involves active transport, which …
Emerging roles of glycopeptide antibiotics: Moving beyond gram-positive bacteria
Glycopeptides, a class of cell wall biosynthesis inhibitors, have been the antibiotics of choice
against drug-resistant Gram-positive bacterial infections. Their unique mechanism of action …
against drug-resistant Gram-positive bacterial infections. Their unique mechanism of action …
Siderophore conjugates
MGP Page - Annals of the New York Academy of Sciences, 2013 - Wiley Online Library
There has been considerable effort expended in the investigation of the potential of
siderophore conjugates of antibiotics to circumvent the permeability barrier imposed by the …
siderophore conjugates of antibiotics to circumvent the permeability barrier imposed by the …
Sideromycins as pathogen-targeted antibiotics
TA Wencewicz, MJ Miller - Antibacterials: Volume II, 2018 - Springer
The overuse of broad-spectrum antibiotics rapidly selects for dangerous multi-drug resistant
bacterial pathogens. The landscape of antibiotic drug discovery is adapting to this wave of …
bacterial pathogens. The landscape of antibiotic drug discovery is adapting to this wave of …
The synthesis of biologically active indolocarbazole natural products
GE Chambers, AE Sayan, RCD Brown - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to 2020 The indolocarbazoles, in particular indolo [2, 3-a] pyrrolo [3, 4-c]
carbazole derivatives, are an important class of natural products that exhibit a wide range of …
carbazole derivatives, are an important class of natural products that exhibit a wide range of …
Iron sequestration by small molecules: thermodynamic and kinetic studies of natural siderophores and synthetic model compounds
AL Crumbliss, JM Harrington - Advances in inorganic chemistry, 2009 - Elsevier
Publisher Summary This chapter discusses researches on natural siderophores and
synthetic siderophore-like molecules, with an emphasis on results from the laboratories over …
synthetic siderophore-like molecules, with an emphasis on results from the laboratories over …
Biotechnology of siderophores in high-impact scientific fields
LO De Serrano - Biomolecular concepts, 2017 - degruyter.com
Different aspects of bacterial and fungal siderophore biotechnological applications will be
discussed. Areas of application presented include, but are not limited to agriculture …
discussed. Areas of application presented include, but are not limited to agriculture …