A highly sensitive and selective electrochemical sensor based on computer-aided design of molecularly imprinted polymer for the determination of leflunomide

A Cetinkaya, SI Kaya, ME Corman, M Karakaya… - Microchemical …, 2022 - Elsevier
This study includes the electrochemical analysis of leflunomide (LEF), used in the treatment
of rheumatoid arthritis, with a molecularly imprinted polymer (MIP) based sensor using …

Development and validation of HPLC method for simultaneous determination of Leflunomide and folic acid in the nanoparticulate system by reversed-phase HPLC

B Siddiqui, H Ahmed, I Haq, A Rehman… - Drug Development and …, 2023 - Taylor & Francis
Objective The main objective of this study was to develop a highly sensitive, accurate, and
reproducible analytical method for the simultaneous detection of LEF and FA in polymeric …

Differential pulse voltammetric determination of an immunosuppressive drug teriflunomide on an edge plane pyrolytic graphite electrode

K Kaczmarska, M Brycht, A Leniart, S Skrzypek - RSC advances, 2017 - pubs.rsc.org
In the present work, sensitive and selective determination of teriflunomide (Trf) on an edge
plane pyrolytic graphite electrode (EPPGE) using differential pulse voltammetry (DPV) is …

A computational evidence of the intermolecular hydrogen bonding in leflunomide: Chemical shielding tensors

F Ektefa, Z Khodadadi, F Naderi, F Fathi - Computational and Theoretical …, 2023 - Elsevier
A computational investigation has been performed without any symmetry constraints at the
B3LYP/6-31++ G** level for the evidencing of hydrogen bonding interactions in the real …

Effect of different exсipients on aqueous solubility of leflunomide. Thermodynamic study

IV Terekhova, DY Kuranov, TV Volkova… - Thermochimica …, 2016 - Elsevier
Leflunomide, an immunosuppressive disease-modifying antirheumatic drug, is sparingly
soluble in aqueous solutions. The aim of this work was to propose the suitable excipients for …

A Computational Evidence of the Intermolecular Hydrogen Bonding in Leflunomide: Chemical Shielding Tensors

F Naderi, Z Khodadadi, F Ektefa, F Fathi - Available at SSRN 4186535 - papers.ssrn.com
A computational investigation have been performed for evidencing the hydrogen bonding
interaction in the real crystalline structure of Leflunomide (LFM) via chemical sheilding (CS) …