Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

Multiple system atrophy (MSA) is an orphan, fatal, adult-onset neurodegenerative disorder of
uncertain etiology that is clinically characterized by various combinations of parkinsonism …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

Protein misfolding and aggregation is a common hallmark in neurodegenerative disorders,
including Alzheimer's disease (AD), Parkinson's disease (PD), and fronto-temporal dementia …

Aggregation of α‐synuclein, an abundant and conserved pre‐synaptic brain protein, is
implicated as a critical factor in several neurodegenerative diseases. These diseases …

Abstract α-Synucleinopathies (ASP) comprise adult-onset, progressive neurodegenerative
disorders such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple …

Although trace levels of phosphorylated α-synuclein (α-syn) are detectable in normal brains,
nearly all α-syn accumulated within Lewy bodies in Parkinson disease brains is …

Multiple system atrophy (MSA) is a fatal adult‐onset neurodegenerative disorder of
uncertain etiology, clinically manifesting with autonomic failure associated with …

Abstract α-Synuclein aggregation is thought to be a key event in the pathogenesis of
synucleinopathies. Although different α-synuclein alterations and modifications have been …

Intracytoplasmic proteinaceous inclusions, primarily composed of tau or α-synuclein (α-syn),
are predominant pathological features of Alzheimer's disease (AD) and Parkinson's disease …