Altered tissue mechanics and metabolism are defining characteristics of cancer that impact
not only proliferation but also migration. While migrating through a mechanically and …

Obesity and metabolic syndrome are strongly associated with cancer, and these disorders
may share a common mechanism. Recently, fructose has emerged as a driving force to …

Rapidly proliferating leukemic progenitor cells consume substantial glucose, which may
lead to glucose insufficiency in bone marrow. We show that acute myeloid leukemia (AML) …

Fructose intake has increased dramatically since humans were hunter‐gatherers, probably
outpacing the capacity of human evolution to make physiologically healthy adaptations …

Harmful effects of high fructose intake on health have been widely reported. Although
fructose is known to promote cancer, little is known about the underlying mechanisms. Here …

Background The response to neoadjuvant chemotherapy (NAC) differs substantially among
individual patients with non‐small cell lung cancer (NSCLC). Major pathological response …

Epidemiologic studies have shown that dietary sugar intake has a significant impact on the
development of breast cancer. One proposed mechanism for how sugar impacts cancer …

Although dietary fructose is associated with an elevated risk for pancreatic cancer, the
underlying mechanisms remain elusive. Here, we report that ketohexokinase (KHK), the rate …

The metabolism of cancer cells is highly plastic. Cancer cells can change their preference
for nutrient uptake under nutrient stress. Fructose is one of the most common carbohydrates …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive type of pancreatic cancer with
clinical characteristics of local invasion and early metastasis. Recent cohort studies indicate …