Graft-versus-host disease (GvHD) is a major complication of allogeneic hematopoietic
(stem) cell transplantation (HCT). Clinically, GvHD is associated with severe and long …

The bone marrow microenvironment houses haematopoietic stem cells (HSC),
mesenchymal stem cells (MSC) and their progeny, supports haematopoiesis, osteogenesis …

In vitro replicas of bone marrow can potentially provide a continuous source of blood cells
for transplantation and serve as a laboratory model to examine human immune system …

In many animals, blood cell production occurs in the bone marrow. Hematopoiesis is
complex, requiring self-renewing and pluripotent stem cells, differentiated progenitor and …

Severe aplastic anemia (AA) is a bone marrow (BM) failure (BMF) disease frequently caused
by aberrant immune destruction of blood progenitors. Although a Th1-mediated pathology is …

Acquired aplastic anemia (AA) is a potentially fatal bone marrow (BM) failure syndrome. IFN-
γ–producing Th1 CD4+ T cells mediate the immune destruction of hematopoietic cells, and …

Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that originate in the
bone marrow (BM) and have immunoregulatory functions. MDSCs have been implicated in …

Severe aplastic anemia (SAA) results from profound hematopoietic stem cell loss. T cells
and interferon gamma (IFNγ) have long been associated with SAA, yet the underlying …

Severe aplastic anemia (SAA) is an acquired, T cell-driven bone marrow (BM) failure
disease characterized by elevated interferon gamma (IFNγ), loss of hematopoietic stem cells …

Aplastic anemia (AA) is an autoimmune disease in which T cell activation is suspected to
play an important role. T cell immunoglobulin and ITIM (immunoreceptor tyrosine‐based …