Chalcone derivatives: role in anticancer therapy
Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - Biomolecules, 2021 - mdpi.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …
which are common simple chemical scaffolds found in many naturally occurring compounds …
Recent developments of gallic acid derivatives and their hybrids in medicinal chemistry: A review
The leading cause of several degenerative diseases such as atherosclerosis, cancer, aging,
cardiovascular, and inflammatory diseases is oxidative stress, a consequence of …
cardiovascular, and inflammatory diseases is oxidative stress, a consequence of …
A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors
Abstract Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is
associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates …
associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates …
Chalcone hybrids as potential anticancer agents: Current development, mechanism of action, and structure‐activity relationship
F Gao, G Huang, J Xiao - Medicinal research reviews, 2020 - Wiley Online Library
The continuous emergency of drug‐resistant cancers and the low specificity of anticancer
agents have been the major challenges in the control and treatment of cancer, making an …
agents have been the major challenges in the control and treatment of cancer, making an …
Naproxen based 1, 3, 4-oxadiazole derivatives as EGFR inhibitors: Design, synthesis, anticancer, and computational studies
MM Alam, S Nazreen, ASA Almalki, AA Elhenawy… - Pharmaceuticals, 2021 - mdpi.com
A library of novel naproxen based 1, 3, 4-oxadiazole derivatives (8–16 and 19–26) has been
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
Synthesis of a new series of pyrazolo [1, 5-a] pyrimidines as CDK2 inhibitors and anti-leukemia
Based on the structural study of previously known CDK2 inhibitors, a new series of pyrazolo
[1, 5-a] pyrimidine derivatives was designed and synthesized. The target compounds were …
[1, 5-a] pyrimidine derivatives was designed and synthesized. The target compounds were …
An understanding of mechanism-based approaches for 1, 3, 4-oxadiazole scaffolds as cytotoxic agents and enzyme inhibitors
The world's health system is plagued by cancer and a worldwide effort is underway to find
new drugs to treat cancer. There has been a significant improvement in understanding the …
new drugs to treat cancer. There has been a significant improvement in understanding the …
[HTML][HTML] New Schiff bases derived from dimethylpyridine-1, 2, 4-triazole hybrid as cytotoxic agents targeting gastrointestinal cancers: Design, synthesis, biological …
M Strzelecka, B Wiatrak, P Jawień, Ż Czyżnikowska… - Bioorganic …, 2023 - Elsevier
In this research, a series of novel hybrid structures of dimethylpyridine-1, 2, 4-triazole Schiff
bases were designed, synthesized, and evaluated for their in vitro cytotoxic potency on …
bases were designed, synthesized, and evaluated for their in vitro cytotoxic potency on …
Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer
EA Abdelsalam, AA Abd El-Hafeez… - Journal of enzyme …, 2022 - Taylor & Francis
New series of thiazolyl-pyrazoline derivatives (7a–7d, 10a–10d and 13a–13f) have been
synthesised and assessed for their potential EGFR and VEGFR-2 inhibitory activities …
synthesised and assessed for their potential EGFR and VEGFR-2 inhibitory activities …
Design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies of new thieno [2, 3-d] pyrimidines targeting VEGFR-2
In this work, new thieno [2, 3-d] pyrimidine-derived compounds possessing potential
anticancer activities were designed and synthesized to target VEGFR-2. The thieno [2, 3-d] …
anticancer activities were designed and synthesized to target VEGFR-2. The thieno [2, 3-d] …