The fetal origins of mental illness

BJS Al-Haddad, E Oler, B Armistead… - American journal of …, 2019 - Elsevier
The impact of infections and inflammation during pregnancy on the developing fetal brain
remains incompletely defined, with important clinical and research gaps. Although the …

Maternal obesity and neurodevelopmental and psychiatric disorders in offspring

AG Edlow - Prenatal diagnosis, 2017 - Wiley Online Library
There is a growing body of evidence from both human epidemiologic and animal studies
that prenatal and lactational exposure to maternal obesity and high‐fat diet are associated …

Environmental factors influencing the risk of autism

P Karimi, E Kamali, SM Mousavi… - Journal of Research in …, 2017 - journals.lww.com
Autism is a developmental disability with age of onset in childhood (under 3 years old),
which is characterized by definite impairments in social interactions, abnormalities in …

Maternal immune activation by poly I: C as a preclinical model for neurodevelopmental disorders: a focus on autism and schizophrenia

FL Haddad, SV Patel, S Schmid - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Maternal immune activation (MIA) in response to a viral infection during early and mid-
gestation has been linked through various epidemiological studies to a higher risk for the …

Influence of infection during pregnancy on fetal development

KMA Waldorf, RM McAdams - Reproduction, 2013 - rep.bioscientifica.com
Infection by bacteria, viruses, and parasites may lead to fetal death, organ injury, or limited
sequelae depending on the pathogen. Here, we consider the role of infection during …

Maternal inflammation disrupts fetal neurodevelopment via increased placental output of serotonin to the fetal brain

N Goeden, J Velasquez, KA Arnold… - Journal of …, 2016 - Soc Neuroscience
Maternal inflammation during pregnancy affects placental function and is associated with
increased risk of neurodevelopmental disorders in the offspring. The molecular mechanisms …

Inflammation and the two-hit hypothesis of schizophrenia

KA Feigenson, AW Kusnecov, SM Silverstein - … & Biobehavioral Reviews, 2014 - Elsevier
The high societal and individual cost of schizophrenia necessitates finding better, more
effective treatment, diagnosis, and prevention strategies. One of the obstacles in this …

[HTML][HTML] Preterm birth: Inflammation, fetal injury and treatment strategies

AK Boyle, SF Rinaldi, JE Norman, SJ Stock - Journal of reproductive …, 2017 - Elsevier
Preterm birth (PTB) is the leading cause of childhood mortality in children under 5 and
accounts for approximately 11% of births worldwide. Premature babies are at risk of a …

The consequences of chorioamnionitis: preterm birth and effects on development

R Galinsky, GR Polglase, SB Hooper… - Journal of …, 2013 - Wiley Online Library
Preterm birth is a major cause of perinatal mortality and long‐term morbidity.
Chorioamnionitis is a common cause of preterm birth. Clinical chorioamnionitis …

[HTML][HTML] The poly (I: C)-induced maternal immune activation model in preclinical neuropsychiatric drug discovery

S Reisinger, D Khan, E Kong, A Berger, A Pollak… - Pharmacology & …, 2015 - Elsevier
Increasing epidemiological and experimental evidence implicates gestational infections as
one important factor involved in the pathogenesis of several neuropsychiatric disorders …