Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

TP53, which encodes the tumour-suppressor protein p53, is the most frequently mutated
gene across all cancer types. The presence of mutant p53 predisposes to cancer …

Even 30 years after its discovery, the tumor suppressor protein p53 is still somewhat of an
enigma. p53's intimate and multifaceted role in the cell cycle is mirrored in its equally …

Over 50% of all human cancers lose p53 function. To evaluate the role of aggregation in
cancer, we asked whether wild-type (WT) p53 and the hot-spot mutant R248Q could …

Eukaryotic cells are intracellularly divided into numerous compartments or organelles, which
coordinate specific molecules and biological reactions. Membrane‐bound organelles are …

TP53 is a tumor suppressor gene that encodes a sequence-specific DNA-binding
transcription factor activated by stressful stimuli; it upregulates target genes involved in …

Amyloids are filamentous protein deposits ranging in size from nanometres to microns and
composed of aggregated peptide β-sheets formed from parallel or anti-parallel alignments of …

Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …

Tetramer formation of p53 is essential for its tumor suppressor function. p53 not only acts as
a tumor suppressor protein by inducing cell cycle arrest and apoptosis in response to …

The global transcription factor, p53, is a master regulator of gene expression in cells.
Mutations in the TP53 gene promote unregulated cell growth through the inactivation of …