Aging with HIV: a practical review

SW Cardoso, TS Torres, M Santini-Oliveira… - Brazilian Journal of …, 2013 - SciELO Brasil
The worldwide elderly population is expected to grow by an additional 694 million people by
2025. By that time, there will be approximately two billion elderly people in the world, most of …

HIV infection and bone disease

J Compston - Journal of internal medicine, 2016 - Wiley Online Library
The success of antiretroviral therapy in treating HIV infection has greatly prolonged life
expectancy in affected individuals, transforming the disease into a chronic condition. A …

Changes in bone turnover and bone loss in HIV-infected patients changing treatment to tenofovir-emtricitabine or abacavir-lamivudine

H Haskelberg, JF Hoy, J Amin, PR Ebeling, S Emery… - PloS one, 2012 - journals.plos.org
Background Those receiving tenofovir/emtricitabine (TDF-FTC) had greater bone loss
compared with abacavir/lamivudine (ABC-3TC) in a randomized simplification trial (STEAL …

Bone mineral density and inflammatory and bone biomarkers after darunavir–ritonavir combined with either raltegravir or tenofovir–emtricitabine in antiretroviral-naive …

JI Bernardino, A Mocroft, PW Mallon, C Wallet… - The lancet HIV, 2015 - thelancet.com
Background Osteopenia, osteoporosis, and low bone mineral density are frequent in
patients with HIV. We assessed the 96 week loss of bone mineral density associated with a …

Higher rates of bone loss in postmenopausal HIV-infected women: a longitudinal study

MT Yin, CA Zhang, DJ McMahon… - The Journal of …, 2012 - academic.oup.com
Context and Objective: The objective of the study was to assess the effects of HIV infection
and antiretroviral therapy on change in bone mineral density (BMD) in postmenopausal …

Low bone mineral density in patients with well-suppressed HIV infection: association with body weight, smoking, and prior advanced HIV disease

KW Kooij, FWNM Wit, PH Bisschop… - The Journal of …, 2015 - academic.oup.com
Background Human immunodeficiency virus (HIV) and combination antiretroviral therapy
(cART) may both contribute to the higher prevalence of osteoporosis and osteopenia in HIV …

HIV protease inhibitors induce senescence and alter osteoblastic potential of human bone marrow mesenchymal stem cells: beneficial effect of pravastatin

SJ Hernandez‐Vallejo, C Beaupere, J Larghero… - Aging cell, 2013 - Wiley Online Library
HIV‐infected patients receiving antiretroviral therapy present an increased prevalence of
age‐related comorbidities, including osteoporosis. HIV protease inhibitors (PI s) have been …

Immediate initiation of antiretroviral therapy for HIV infection accelerates bone loss relative to deferring therapy: findings from the START bone mineral density …

JF Hoy, B Grund, M Roediger… - Journal of bone and …, 2017 - academic.oup.com
Both HIV infection and antiretroviral therapy (ART) are associated with lower bone mineral
density (BMD) and increased fracture risk. Because the relative contributions of ART and …

Ageing with HIV

P McGettrick, E Alvarez Barco, PWG Mallon - Healthcare, 2018 - mdpi.com
The population of people living with HIV (PLWH) is growing older with an estimated 4 million
over the age of 50 years, a figure which has doubled since the introduction of effective …

Is bone loss linked to chronic inflammation in antiretroviral-naive HIV-infected adults? A 48-week matched cohort study

CO Hileman, DE Labbato, NJ Storer, V Tangpricha… - Aids, 2014 - journals.lww.com
Objective: Antiretroviral therapy (ART) has been implicated in bone loss in HIV. The role of
inflammation and vitamin D is unclear and better investigated in ART-naive individuals …