Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …

Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local
diseases, direct access to unique therapeutic targets and the potential for increasing …

Orally administrable anticancer nanomedicines are highly desirable due to their easy and
repeatable administration, but are not yet feasible because the current nanomedicine cannot …

Highlights•Clearance routes of nanoparticles in the lung are presented.•Factors influencing
nanoparticle transaction are discussed.•Physicochemical properties of the nanoparticles …

We review what is currently understood about how the structure of the primary solid
component of mucus, the glycoprotein mucin, gives rise to the mechanical and biochemical …

Pulmonary drug delivery is a highly attractive topic for the treatment of infectious lung
diseases. Drug delivery via the pulmonary route offers unique advantages of no first-pass …

Inhaled siRNA therapy has a unique potential for treatment of severe lung diseases, such as
cystic fibrosis (CF). Nevertheless, a drug delivery system tackling lung barriers is mandatory …

Mucosal vaccines can effectively induce an immune response at the mucosal site and form
the first line of defense against microbial invasion. The induced mucosal immunity includes …

Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in
the human body. High vascularization and accessibility have motivated drug delivery to …

As of today, the era of nanomedicine has brought numerous breakthroughs and overcome
challenges in the treatment of various disorders. Various factors like size, charge and …