Inflammasomes are newly recognized, vital players in innate immunity. The best
characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the …

Identification of thioredoxin binding protein-2 (TBP-2), which is currently known as
thioredoxin interacting protein (TXNIP), as an important binding partner for thioredoxin (TRX) …

Abstract NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein
(TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in …

Background Neuroinflammation and oxidative stress play important roles in early brain
injury following subarachnoid hemorrhage (SAH). This study is the first to show that …

Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, has been
shown to inhibit cerebral ischemic injury. However, its potential molecular action on blood …

Subarachnoid hemorrhage (SAH) is a devastating condition with high morbidity and
mortality rates due to the lack of effective therapy. Nucleotide‐binding oligomerization …

Neurological diseases, including acute attacks (eg, ischemic stroke) and chronic
neurodegenerative diseases (eg, Alzheimer's disease), have always been one of the …

The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-
containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and …

Unfolded protein response (UPR) is an adaptive response which is used for re-establishing
protein homeostasis, and it is triggered by endoplasmic reticulum (ER) stress. Specific ER …

Endoplasmic reticulum (ER) stress, which is highly associated with cardiovascular disease,
is triggered by a disturbance in ER function because of protein misfolding or an increase in …