Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma
membrane (PM) macropores composed of gasdermin‐family (GSDM) proteins. It facilitates …

The major function of the mammalian immune system is to prevent and control infections
caused by enteropathogens that collectively have altered human destiny. In fact, as the …

The type III secretion system (T3SS) is an appendage used by many bacterial pathogens,
such as pathogenic Yersinia, to subvert host defenses. However, because the T3SS is …

Hemachromatosis (iron-overload) increases host susceptibility to siderophilic bacterial
infections that cause serious complications, but the underlying mechanisms remain elusive …

It is well-documented that type-III effectors are required by Gram-negative pathogens to
directly target different host cellular pathways to promote bacterial infection. However, in the …

Modern lifestyle changes, especially the consumption of a diet high in salt, sugar, and fat,
have contributed to the increasing incidence and prevalence of chronic metabolic diseases …

Many pathogens secrete effectors to hijack intracellular signaling regulators in host immune
cells to promote pathogenesis. However, the pathogenesis of Staphylococcus aureus …

Abstract The multifunctional Yersinia effector YopM inhibits effector triggered immunity and
increases production of the anti-inflammatory cytokine Interleukin-10 (IL-10) to suppress the …

Translocon pores formed in the eukaryotic cell membrane by a type III secretion system
facilitate the translocation of immune-modulatory effector proteins into the host cell interior …

Objective Mouse infection models are frequently used to study the host–pathogen
interaction studies. However, due to several constraints, there is an urgent need for a simple …