Nuclear receptors and their selective pharmacologic modulators
Nuclear receptors are ligand-activated transcription factors and include the receptors for
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …
Tissue selective estrogen complex (TSEC): a review
JH Pickar, M Boucher, D Morgenstern - Menopause, 2018 - journals.lww.com
Objective: This review describes historical development of selective estrogen receptor
modulators (SERMs) and their combination with estrogens, termed a tissue selective …
modulators (SERMs) and their combination with estrogens, termed a tissue selective …
Estrogen promotes the development of mouse cumulus cells in coordination with oocyte-derived GDF9 and BMP15
K Sugiura, YQ Su, Q Li, K Wigglesworth… - Molecular …, 2010 - academic.oup.com
The differentiation and function of cumulus cells depend upon oocyte-derived paracrine
factors, but studies on the estrogen receptor knockout mice suggested that estrogen also …
factors, but studies on the estrogen receptor knockout mice suggested that estrogen also …
Nuclear receptor modulation–role of coregulators in selective estrogen receptor modulator (SERM) actions
Q Feng, BW O'Malley - Steroids, 2014 - Elsevier
Selective estrogen receptor modulators (SERMs) are a class of small-molecule chemical
compounds that bind to estrogen receptor (ER) ligand binding domain (LBD) with high …
compounds that bind to estrogen receptor (ER) ligand binding domain (LBD) with high …
Characterization of the novel duplicated PRLR gene at the late-feathering K locus in Lohmann chickens
G Bu, G Huang, H Fu, J Li, S Huang… - Journal of molecular …, 2013 - jme.bioscientifica.com
Transcriptional regulation of the steroidogenic acute regulatory (StAR) protein gene by
cAMP-dependent mechanisms occurs in the absence of a consensus cAMP-response …
cAMP-dependent mechanisms occurs in the absence of a consensus cAMP-response …
Molecular spectroscopic and molecular simulation studies on the interaction of oral contraceptive drug Ormeloxifene with CT–DNA
S Ponkarpagam, KN Vennila, KP Elango - Spectrochimica Acta Part A …, 2022 - Elsevier
The interaction between oral contraceptive drug Ormeloxifene (ORM) and calf thymus DNA
(CT–DNA) was studied using UV–Vis, fluorescence, circular dichroism (CD) and 1 H NMR …
(CT–DNA) was studied using UV–Vis, fluorescence, circular dichroism (CD) and 1 H NMR …
Spiro-oxindole derivative 5-chloro-4′, 5′-diphenyl-3′-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro [indoline-3, 2′-pyrrolidin]-2-one triggers apoptosis in breast …
Breast cancer remains a significant health problem due to the involvement of multiple
aberrant and redundant signaling pathways in tumorigenesis and the development of …
aberrant and redundant signaling pathways in tumorigenesis and the development of …
[HTML][HTML] Ormeloxifene inhibits osteoclast differentiation in parallel to downregulating RANKL-induced ROS generation and suppressing the activation of ERK and JNK …
Ormeloxifene (Orm), a triphenylethylene compound, has been established as a selective
estrogen receptor modulator (SERM) that suppresses the ovariectomy-induced bone …
estrogen receptor modulator (SERM) that suppresses the ovariectomy-induced bone …
Centchroman induces redox-dependent apoptosis and cell-cycle arrest in human endometrial cancer cells
Centchroman (CC) or Ormeloxifene has been shown to induce apoptosis and cell cycle
arrest in various types of cancer cells. This has, however, not been addressed for …
arrest in various types of cancer cells. This has, however, not been addressed for …
Selective estrogen receptor modulator ormeloxifene suppresses embryo implantation via inducing miR-140 and targeting insulin-like growth factor 1 receptor in rat …
Highlights•Ormeloxifene induces miR-140 expression in rat uterus.•Expression of miR-140
is regulated by estradiol.•Over-expression of miR-140 inhibited embryo implantation in …
is regulated by estradiol.•Over-expression of miR-140 inhibited embryo implantation in …