Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Emerging Burden

S Batool, K Morton Cuthrell, N Tzenios… - … Research Journal of …, 2022 - publish7promo.com
Liver is the largest solid organ in the body that performs over 100 functions. It removes the
toxins and waste products from the blood stream, maintains healthy blood sugar levels …

Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease

CK Negi, P Babica, L Bajard, J Bienertova-Vasku… - Metabolism, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
worldwide. With no Food and Drug Administration approved drugs, current treatment options …

Senolytic CAR T cells reverse senescence-associated pathologies

C Amor, J Feucht, J Leibold, YJ Ho, C Zhu… - Nature, 2020 - nature.com
Cellular senescence is characterized by stable cell-cycle arrest and a secretory program that
modulates the tissue microenvironment,. Physiologically, senescence serves as a tumour …

CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells

Y Koda, T Teratani, PS Chu, Y Hagihara… - Nature …, 2021 - nature.com
Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease that can
progress to liver fibrosis. Recent clinical advance suggests a reversibility of liver fibrosis, but …

Liver fibrosis in non-alcoholic fatty liver disease: from liver biopsy to non-invasive biomarkers in diagnosis and treatment

LJM Heyens, D Busschots, GH Koek, G Robaeys… - Frontiers in …, 2021 - frontiersin.org
An increasing percentage of people have or are at risk to develop non-alcoholic fatty liver
disease (NAFLD) worldwide. NAFLD comprises different stadia going from isolated steatosis …

Triggering and resolution of inflammation in NASH

S Schuster, D Cabrera, M Arrese… - Nature reviews …, 2018 - nature.com
Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …

Antioxidant peptides from monkfish swim bladders: ameliorating NAFLD in vitro by suppressing lipid accumulation and oxidative stress via regulating AMPK/Nrf2 …

MF Wu, QH Xi, Y Sheng, YM Wang, WY Wang, CF Chi… - Marine drugs, 2023 - mdpi.com
In this study, we investigate the ameliorating functions of QDYD (MSP2), ARW (MSP8),
DDGGK (MSP10), YPAGP (MSP13) and DPAGP (MSP18) from monkfish swim bladders on …

[HTML][HTML] Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)

YY Qiu, J Zhang, FY Zeng, YZ Zhu - Pharmacological Research, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease phenotypes
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

A Deczkowska, E David, P Ramadori, D Pfister… - Nature medicine, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are
prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver …

Cellular senescence drives age-dependent hepatic steatosis

M Ogrodnik, S Miwa, T Tchkonia, D Tiniakos… - Nature …, 2017 - nature.com
The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular
senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of …