Collectively, the completion of the Human Genome Project and subsequent development of
high-throughput next-generation sequencing methodologies have revolutionized genomic …

Precision medicine strives to delineate disease using multiple data sources—from genomics
to digital health metrics—in order to be more precise and accurate in our diagnoses …

The acquired and congenital forms of long QT syndrome represent 2 distinct but clinically
and genetically intertwined disorders of cardiac repolarization characterized by the shared …

Background Gastrointestinal sensorimotor dysfunction underlies a wide range of
esophageal, gastric, and intestinal motility and functional disorders that collectively …

Dear Editor, Loss or dysfunction of cardiomyocytes lead to heart failure which is a leading
cause of death worldwide. 1 It is widely known that the hearts of adult mammals have a very …

Epigenetic modifications offer compelling evidence of the environmental etiology of complex
diseases. Social and biographical conditions, as well as material exposures, all modulate …

Genetic variants play an important role in conferring risk for cardiovascular diseases (CVDs).
With the rapid development of next-generation sequencing (NGS), thousands of genetic …

Background Many rare, potentially pathogenic, RYR2 variants identified in individuals with
clinically definite catecholaminergic polymorphic ventricular tachycardia are classified …

Background Although largely preventable, cardiovascular diseases (CVDs) are the biggest
cause of death worldwide. Common complex cardiovascular disorders (eg, coronary heart …

Cardiovascular genetic counseling (CVGC) is recommended for a variety of inherited heart
conditions; however, its impact on patient empowerment has not been assessed. The …