Meiosis is the chromosomal foundation of reproduction, with errors in this important process
leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the …

The decline in fertility in aging women, especially those with poor ovarian response (POR)
or primary ovarian insufficiency (POI), is a major concern for modern IVF centers. Fertility …

Polycystic ovary syndrome (PCOS) continues to be one of the most complex reproductive
and endocrine disorder among women of reproductive age. Recent reports have identified …

Patients with hematologic malignancies and those undergoing hematopoietic cell
transplantation (HCT) face a complex set of challenges when considering options for fertility …

Infertile couples including cancer survivors stand to benefit from gametes differentiated from
embryonic or induced pluripotent stem (ES/iPS) cells. It remains challenging to convert …

It is generally accepted that significant germ cell loss occurs during the establishment of the
primordial follicle pool in most mammalian ovaries around the time of birth. However, the …

Oocytes spend the majority of their lifetime in a primordial state. The cellular and molecular
biology of primordial oocytes is largely unexplored; yet, it is necessary to study them to …

This study aims to evaluate the effects of melatonin and its mechanisms of action on
preantral follicle activation and survival, stromal cell density and collagen distribution in …

Although only a small number of primordial follicles are known to be selectively activated
during female reproductive cycles, the mechanisms that trigger this recruitment remain …

Follicle stimulating hormone (FSH) is secreted by the anterior pituitary and acts on the germ
cells indirectly through Granulosa cells in ovaries and Sertoli cells in the testes …