Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

G-protein-coupled receptors (GPCRs) are physiologically important membrane proteins that
sense signalling molecules such as hormones and neurotransmitters, and are the targets of …

The third intracellular loop (ICL3) of the G protein-coupled receptor (GPCR) fold is important
for the signal transduction process downstream of receptor activation,–. Despite this, the lack …

The adenosine class of heterotrimeric guanine nucleotide–binding protein (G protein)–
coupled receptors (GPCRs) mediates the important role of extracellular adenosine in many …

An easy-to-use, versatile and freely available graphic web server, FoldIndex© is described:
it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of …

Advances in structural biology have provided important mechanistic insights into signaling
by the transmembrane core of G-protein coupled receptors (GPCRs); however, much less is …

Systematic efforts to understand membrane protein stability under a variety of different
solution conditions are not widely available for membrane proteins, mainly due to technical …

Diane Lynch1, Dow Hurst1, Patti Reggio1, Alan Grossfield2, Mike Pitman3. 1University of
North Carolina, Greensboro, Greensboro, NC, USA, 2University of Rochester School of …

Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …

The traditional view on GPCRs held that they function as single monomeric units composed
of identical subunits. This notion was overturned by the discovery that GPCRs can form …