Providing the appropriate quantity and quality of food needed for both the mother's well-
being and the healthy development of the offspring is crucial during pregnancy. However …

Microglia are dynamic cells, constantly surveying their surroundings and interacting with
neurons and synapses. Indeed, a wealth of knowledge has revealed a critical role of …

Background Maternal nutrition is critical for proper fetal development. While increased
nutrient intake is essential during pregnancy, an excessive consumption of certain nutrients …

Background Production of inflammatory mediators by reactive microglial cells in the brain is
generally considered the primary mechanism underlying the development of symptoms of …

Microglia, the key neuroimmune cells of the central nervous system, are best known for their
function in defending an individual from pathogens and injury. Recent findings, including our …

Children exposed prenatally to opioids are at an increased risk for behavioral problems and
executive function deficits. The prefrontal cortex (PFC) and amygdala (AMG) regulate …

Within the national opioid epidemic, there has been an increase in the number of infants
exposed to opioids in utero. Additionally, opioid agonist medications are the standard of …

Single prolonged stress (SPS) is a preclinical rodent model for studying post-traumatic
stress disorder (PTSD)-like behaviors. Previously we found that increased expression of the …

Maternal high-fat diets (HFD) can generate inflammation in the offspring's amygdala, which
can lead to anxiety-like behaviors. Conversely, lipopolysaccharide (LPS) tolerance can …

The use of psychostimulant drugs can modify brain function by inducing changes in the
reward system, mainly due to alterations in dopaminergic and glutamatergic transmissions …