Collagen denaturation in post-run Achilles tendons and Achilles tendinopathy: In vivo mechanophysiology and magnetic resonance imaging

Y Fang, D Zhu, J Wei, L Qian, R Qiu, T Jia, K Huang… - Science …, 2024 - science.org
Achilles tendinopathy is often attributed to overuse, but its pathophysiology remains poorly
understood. Disruption to the molecular structure of collagen is fundamental for the onset …

Moderate‐and High‐Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon

MK Tamburro, KA Bonilla, SS Shetye… - Journal of …, 2024 - Wiley Online Library
Exercise influences clinical Achilles tendon health in humans, but animal models of exercise‐
related Achilles tendon changes are lacking. Moreover, previous investigations of the effects …

Author Spotlight: Unraveling the Mechanobiology of Tendon Impingement–A Multiaxial Murine Hind Limb Explant Model

BC Wise, KE Mora, W Lee, MR Buckley - JoVE (Journal of Visualized …, 2023 - jove.com
Tendon impingement upon bone generates a multiaxial mechanical strain environment with
markedly elevated transverse compressive strain, which elicits a localized fibrocartilage …

Novel models of tendinopathy on a chip

BE Garcia Sanchez - 2024 - qmro.qmul.ac.uk
An organ-on-a-chip (OOAC) is an engineered model, designed to capture native organ
architecture, functions, and physiochemical environments for use in discovery science or …

In Situ and In Vivo Roles of Focal Adhesion Kinase in Tendon Development and Mechanotransduction

TP Leahy - 2023 - search.proquest.com
Tendons enable locomotion by transmitting high tensile mechanical forces between muscle
and bone via their dense extracellular matrix (ECM). The application of extrinsic mechanical …