The superfamily of G protein-coupled receptors (GPCRs) mediates a wide range of
physiological responses and serves as an important category of drug targets. Earlier …

Fluorescence spectroscopy has become an established tool at the interface of biology,
chemistry and physics because of its exquisite sensitivity and recent technical …

Solid lipid nanoparticles (SLN) were invented in 1991 as a delivery system combining
advantages of other nanoparticulate systems and at the same time avoiding/minimizing …

Arrestins are regulatory molecules for G-protein coupled receptor function. In visual
rhodopsin, selective binding of arrestin to the cytoplasmic side of light-activated …

Lipid nanoparticles have gained increased interest in the field of dermal products because
of various advantages such as improved drug absorption and controlled drug release. The …

The question whether nanoparticles can cross the skin barrier is highly debated. Even in
intact skin rare events of deeper penetration have been reported, but technical limitations …

Drug loading capacity in nanostructured lipid carriers (NLC) depends on the formation of
nanostructures within the lipid matrix. However, investigation of these nanostructures with …

Little is known about the molecular nature of residual structure in unfolded states of
membrane proteins. A screen of chemical denaturants to maximally unfold the mammalian …

We report here on the application of laser-based single molecule total internal reflection
fluorescence microscopy (TIRFM) to study the penetration of molecules through the skin …

The mechanisms of drug–receptor interactions and the controlled delivery of drugs via
biodegradable and biocompatible nanoparticulate carriers are active research fields in …