Erythrocyte metabolism

PN Chatzinikolaou, NV Margaritelis… - Acta …, 2024 - Wiley Online Library
Our aim is to present an updated overview of the erythrocyte metabolism highlighting its
richness and complexity. We have manually collected and connected the available …

Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease

Y Qiang, A Sissoko, ZL Liu, T Dong… - Proceedings of the …, 2023 - National Acad Sciences
The spleen clears altered red blood cells (RBCs) from circulation, contributing to the balance
between RBC formation (erythropoiesis) and removal. The splenic RBC retention and …

Mechanoinformatics: High-throughput single cell mechanical properties mapping to unravel cell heterogeneity

Q Hu, W Sun, F Lin, C Xiong - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Mechanical properties of cells are not only unique intrinsic labels of cells, but also closely
related to the behaviors and functions of cells under various physiological and pathological …

Antioxidant Activity of Quercetin in a H2O2-Induced Oxidative Stress Model in Red Blood Cells: Functional Role of Band 3 Protein

A Remigante, S Spinelli, E Straface… - International journal of …, 2022 - mdpi.com
During their lifespan, red blood cells (RBCs) are exposed to a large number of stressors and
are therefore considered as a suitable model to investigate cell response to oxidative stress …

Modified red blood cells as multimodal standards for benchmarking single-cell cytometry and separation based on electrical physiology

A Salahi, C Honrado, A Rane, F Caselli… - Analytical …, 2022 - ACS Publications
Biophysical cellular information at single-cell sensitivity is becoming increasingly important
within analytical and separation platforms that associate the cell phenotype with markers of …

Biomechanics of phagocytosis of red blood cells by macrophages in the human spleen

H Li, Y Qiang, X Li, C Brugnara, PA Buffet… - Proceedings of the …, 2024 - pnas.org
The clearance of senescent and altered red blood cells (RBCs) in the red pulp of the human
spleen involves sequential processes of prefiltration, filtration, and postfiltration. While prior …

Single-cell characterization of deformation and dynamics of mesenchymal stem cells in microfluidic systems: A computational study

X Qi, S Ma, X Jiang, H Wu, J Zheng, S Wang, K Han… - Physical Review E, 2023 - APS
Understanding the homing dynamics of individual mesenchymal stem cells (MSCs) in
physiologically relevant microenvironments is crucial for improving the efficacy of MSC …

In silico and in vitro study of the adhesion dynamics of erythrophagocytosis in sickle cell disease

G Li, Y Qiang, H Li, X Li, M Dao, GE Karniadakis - Biophysical Journal, 2023 - cell.com
Erythrophagocytosis occurring in the spleen is a critical process for removing senescent and
diseased red blood cells (RBCs) from the microcirculation. Although some progress has …

Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke

K Wang, W Zhou, X Jin, X Shang, X Wu, L Wen, S Li… - Nanoscale, 2023 - pubs.rsc.org
Ischemic stroke is characterized by high morbidity, disability, and mortality. Unfortunately,
the only FDA-approved pharmacological thrombolytic, alteplase, has a narrow therapeutic …

Evolution of surface area and membrane shear modulus of matured human red blood cells during mechanical fatigue

Q Wei, X Wang, C Zhang, M Dao, X Gong - Scientific Reports, 2023 - nature.com
Mechanical properties of red blood cells (RBCs) change during their senescence which
supports numerous physiological or pathological processes in circulatory systems by …