Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Developmental and epileptic encephalopathies are rare, treatment-resistant epilepsies with
high seizure burden and non-seizure comorbidities. The antiseizure medication (ASM) …

Renal fibrosis commonly leads to glomerulosclerosis and renal interstitial fibrosis and the
main pathological basis involves tubular atrophy and the abnormal increase and excessive …

TNF-α (tumor necrosis factor-alpha) is the best known as a proinflammatory cytokine; yet,
this cytokine also has important immunomodulatory and regulatory functions. As the effects …

Background. Lymphatic metastasis is a common phenomenon of cervical cancer. Tumor
necrosis factor‐α (TNF‐α) was found to be closely associated with lymphatic cancer …

Kidney disease encompasses a complex set of diseases that can aggravate or start systemic
pathophysiological processes through their complex metabolic mechanisms and effects on …

Accumulating data confirms that Methotrexate (MTX), a well-known immunosuppressive and
anticancer drug, causes nephrotoxicity. Infliximab (INF), the inhibitor of tumor necrosis factor …

Acute kidney injury (AKI) causes over 1 million deaths worldwide every year. AKI is now
recognized as a major risk factor in the development and progression of chronic kidney …

Abstract Matrix metalloproteinase-2 (MMP-2) and cluster of differentiation 147 (CD147) both
play important roles in the development of kidney fibrosis, and CD147 can induce the …

Premenopausal females are protected from angiotensin II (ANG II)-induced hypertension
following the adoptive transfer of T cells from normotensive donors. For the present study …