[HTML][HTML] EG-VEGF silencing inhibits cell proliferation and promotes cell apoptosis in pancreatic carcinoma via PI3K/AKT/mTOR signaling pathway
X Yan, Y Hui, Y Hua, L Huang, L Wang, F Peng… - Biomedicine & …, 2019 - Elsevier
Objective Pancreatic carcinoma (PC), one of the most prevalent and malignant tumors, has a
poor prognosis and a high mortality rate. EG-VEGF, a vascular endothelial growth factor …
poor prognosis and a high mortality rate. EG-VEGF, a vascular endothelial growth factor …
[HTML][HTML] The Pyridone-Annelated Isoindigo (5 '-Cl) Induces Apoptosis, Dysregulation of Mitochondria and Formation of ROS in Leukemic HL-60 Cells
Background/Aims: In our quest to develop an isoindigo with improved efficacy and
bioavailability, we recently synthesized a series of novel substituted pyridone-annelated …
bioavailability, we recently synthesized a series of novel substituted pyridone-annelated …
[HTML][HTML] Antiproliferative activity of the isoindigo 5′-Br in HL-60 cells is mediated by apoptosis, dysregulation of mitochondrial functions and arresting cell cycle at G0 …
Abstract Our new compound, 5′-Br [(E)-1-(5′-bromo-2′-oxoindolin-3′-ylidene)-6-ethyl-
2, 3, 6, 9-tetrahydro-2, 9-dioxo-1H-pyrrolo [3, 2-f] quinoline-8-carboxylic acid], had shown …
2, 3, 6, 9-tetrahydro-2, 9-dioxo-1H-pyrrolo [3, 2-f] quinoline-8-carboxylic acid], had shown …
Docking-guided exploration of the anti-flt3 potential of isoindigo derivatives towards potential treatments of acute myeloid leukemia
FMS-like tyrosine kinase 3 (Flt3) is an oncogenic kinase implicated in leukemia, with its
primary association being acute myeloid leukemia (AML). Flt3-specific inhibitors have …
primary association being acute myeloid leukemia (AML). Flt3-specific inhibitors have …
[HTML][HTML] The anticancer activity of the substituted pyridone-annelated isoindigo (5'-Cl) involves G0/G1 cell cycle arrest and inactivation of CDKs in the promyelocytic …
Background/Aims: The antileukemic potential of isoindigos make them desired candidates
for understanding their mechanism of action. We have recently synthesized a novel group of …
for understanding their mechanism of action. We have recently synthesized a novel group of …
Synthesis of isatin-conjugated 3H-indole-N-oxides and their serendipitous conversion to spiroindolenines
HJ Roh, G Kim, S Cho, JY Ryu, J Lee, JN Kim - Tetrahedron Letters, 2018 - Elsevier
Abstract Isatin-conjugated 3H-indole-N-oxides were synthesized from isatin-derived
propargylic alcohols and nitrosobenzenes in moderate yields. Isatin-conjugated 3H-indole …
propargylic alcohols and nitrosobenzenes in moderate yields. Isatin-conjugated 3H-indole …
Quinoline-based compound BPIQ exerts anti-proliferative effects on human retinoblastoma cells via modulating intracellular reactive oxygen species
KC Cheng, CT Hung, KJ Chen, WC Wu… - Archivum Immunologiae …, 2016 - Springer
Retinoblastoma (Rb) is the most common primary intraocular malignant tumor of childhood.
It is important to develop the strategy for Rb treatment. We have tested a quinolone …
It is important to develop the strategy for Rb treatment. We have tested a quinolone …
Synthesis and antitumor activity of model cyclopentene-[g]annelated isoindigos
A set of cyclopenten-[g] annelated isoindigos (5a–g) has been prepared and tested for their
in vitro antiproliferative activities against MCF-7 and HL60 cells. Among, the N-1-methyl-5 …
in vitro antiproliferative activities against MCF-7 and HL60 cells. Among, the N-1-methyl-5 …
[HTML][HTML] Nanoscale isoindigo-carriers: self-assembly and tunable properties
TN Pashirova, AV Bogdanov, LI Musin… - Beilstein Journal of …, 2017 - beilstein-journals.org
Over the last decade isoindigo derivatives have attracted much attention due to their high
potential in pharmacy and in the chemistry of materials. In addition, isoindigo derivatives can …
potential in pharmacy and in the chemistry of materials. In addition, isoindigo derivatives can …
The first synthesis of cis-N, N′-dialkylisoindigo derivatives from 3-indolyl-2-oxindoles with DDQ
HJ Roh, HY Jo, S Cho, JN Kim - Tetrahedron letters, 2018 - Elsevier
Abstract cis-N, N′-Dialkylisoindigo derivatives were synthesized for the first time by the
reaction of 3-indolyl-2-oxindoles with DDQ in aqueous 1, 4-dioxane. cis-Isoindigo …
reaction of 3-indolyl-2-oxindoles with DDQ in aqueous 1, 4-dioxane. cis-Isoindigo …