Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after
severe injury caused by autoimmune reactions, mechanical stress or infections. The …

The lectin pathway of the complement system has a pivotal role in the defense against
infectious organisms. After binding of mannan-binding lectin (MBL), ficolins or collectin 11 to …

Hepatitis C virus (HCV) is a leading cause of chronic liver disease. The identification and
characterization of key host cellular factors that play a role in the HCV replication cycle are …

Hepatitis C virus contact and infection show three different phenotypes: spontaneous viral
clearance (SVC), chronic hepatitis C (CHC) and sustained virological response (SVR) …

Mannan binding lectin (MBL) is a pattern recognition molecule of the innate immune system
that binds to sugars on the surface of invading micro-organisms. Target binding …

Contact with HCV triggers the activation of innate mechanisms responsible for initial
infection control. Host cells expressed extra-or intracellularly molecules that promote …

Infection with Hepatitis C Virus (HCV) causes chronic disease in approximately 80% of
cases, resulting in chronic inflammation and cirrhosis. Current treatments are not completely …

Mannan-binding lectin (MBL) is a soluble innate immune protein that binds to glycosylated
targets. MBL acts as an opsonin and activates complement, contributing to the destruction …

Hepatitis C virus (HCV) is a major cause of hepatic disease and of liver transplantation
worldwide. Mannan-binding lectin (MBL), encoded by the MBL2 gene, can have an …

Due to its importance both in the clearance of pathogens that contribute as rheumatic
etiological agents and in the disposal of apoptotic bodies and potential autoimmune …