Hereditary fructose intolerance is a rare, but potentially lethal, inherited disorder of fructose
metabolism, caused by mutation of the aldolase B gene. Treatment currently relies solely on …

Under normal physiological conditions, the brain utilizes only a small number of carbon
sources for energy. Recently, there is growing molecular and biochemical evidence that …

Both thermophilic and hyperthermophilic enzymes in bacterial and archaeal species are
activated above a specific temperature threshold but inactivated at another higher …

Thermostability is important for the thermoactivity of proteins including enzymes. However, it
is still challenging to pinpoint the specific structural factors for different temperature …

Hereditary fructose intolerance (HFI) is an inborn error of fructose metabolism of autosomal
recessive inheritance caused by pathogenic variants in the ALDOB gene that lead to …

Oligomerization has been suggested to be an important mechanism for increasing or
maintaining the thermostability of proteins. Although it is evident that protein–protein …

Antimicrobial preservatives (eg, benzyl alcohol), which are required in multidose
formulations, can induce protein aggregation. In this study, the mechanism of benzyl alcohol …

Mutations in the aldolase B gene (ALDOB) impairing enzyme activity toward fructose-1-
phosphate cleavage cause hereditary fructose intolerance (HFI). Diagnosis of the disease is …

Hereditary fructose intolerance (HFI) is a potentially fatal inherited metabolic disease caused
by a deficiency of aldolase B activity in the liver and kidney. Over 40 disease-causing …

Hereditary fructose intolerance (HFI) is a potentially lethal inborn error in metabolism caused
by mutations in the aldolase B gene, which is critical for gluconeogenesis and fructose …