TNF acts as one pathogenic driver for inducing intestinal epithelial cell (IEC) death and
substantial intestinal inflammation. How the IEC death is regulated to physiologically prevent …

Deciphering the intricate dynamic events governing type I interferon (IFN) signaling is critical
to unravel key regulatory mechanisms in host antiviral defense. Here, we leverage TurboID …

African swine fever (ASF) is an acute, hemorrhagic, and severe infectious disease caused
by ASF virus (ASFV) infection. At present, there are still no safe and effective drugs and …

Abstract Type I interferons (IFN-I) are implicated in exacerbation of tuberculosis (TB), but the
mechanisms are unclear. Mouse macrophages infected with Mycobacterium tuberculosis …

To investigate the protective role of immune response gene 1 (IRG1) and exogenous
itaconate in autoimmune hepatitis (AIH) and elucidate the underlying mechanisms. Wild …

In their environment, cells must cope with mechanical stresses constantly. Among these,
nanoscale deformations of plasma membrane induced by substrate nanotopography are …

Abstract Type I Interferons (IFNs) generally have a protective role during viral infections, but
their function during bacterial infections is dependent on the bacterial species. Legionella …

Deciphering the intricate dynamic events governing type I interferon (IFN) signaling is critical
to unravel key regulatory mechanisms in host antiviral defense. Here, we leveraged TurboID …

Amongst the different clathrin structures in mammalian cells, bi-layered clathrin coat
colocalizing with endosomal sorting complex required for transport (ESCRT)-0 remains one …

Activation of JAK/STAT signaling by IFN-g requires partitioning of IFN-gR into specific lipid
nanodomains at the plasma membrane. Using IFN-gR as a proxy, we investigated the role of …