The poor outcome of patients with non-surgically removable advanced hepatocellular
carcinoma (HCC), the most frequent type of primary liver cancer, is mainly due to the high …

Double‐strand breaks (DSBs) are the most detrimental DNA damage encountered by
bacterial cells. DBSs can be repaired by homologous recombination thanks to the …

Although Cas9-mediated genome editing has proven to be a powerful genetic tool in
eukaryotes, its application in Bacteria has been limited because of inefficient targeting or …

There has long been a fascination in the DNA repair pathways of archaea, for two main
reasons. Firstly, many archaea inhabit extreme environments where the rate of physical …

Archaea often thrive in environmental extremes, enduring levels of heat, pressure, salinity,
pH, and radiation that prove intolerable to most life. Many environmental extremes raise the …

A percentage of colorectal cancer (CRC) patients display low sensitivity to radiotherapy,
which affects its therapeutic effect. Cancer cells DNA double-strand breaks (DSBs) repair …

Genomes acquire lesions that can block the replication fork and some lesions must be
bypassed to allow survival. The nuclear genome of flowering plants encodes two family-A …

The structural determination and characterization of molecules, namely proteins and
enzymes, is crucial to gaining a better understanding of their role in different chemical and …

DNA double-strand breaks are the most lethal form of damage for living organisms. The non-
homologous end joining (NHEJ) pathway can repair these breaks without the use of a DNA …

DNA double-strand breaks (DSBs) are a threat to genome stability. In all domains of life,
DSBs are faithfully fixed via homologous recombination. Recombination requires the …