Dextran sulfate nanocarriers: design, strategies and biomedical applications

S Ramasundaram, G Saravanakumar, S Sobha… - International journal of …, 2022 - mdpi.com
Dextran sulfate (DXS) is a hydrophilic, non-toxic, biodegradable, biocompatible and safe
biopolymer. These biomedically relevant characteristics make DXS a promising building …

Chitosan based microRNA nanocarriers

HH Genedy, T Delair, A Montembault - Pharmaceuticals, 2022 - mdpi.com
Vectorization of microRNAs has shown to be a smart approach for their potential delivery to
treat many diseases (ie, cancer, osteopathy, vascular, and infectious diseases). However …

Evaluation of photodynamic therapy on nanoparticles and films loaded-nanoparticles based on chitosan/alginate for curcumin delivery in oral biofilms

ALP Silvestre, AM Dos Santos, AB de Oliveira… - International Journal of …, 2023 - Elsevier
Nanoparticles and nanoparticle-loaded films based on chitosan/sodium alginate with
curcumin (CUR) are promising strategies to improve the efficacy of antimicrobial …

Chitosan-based polyelectrolyte complex cryogels with elasticity, toughness and delivery of curcumin engineered by polyions pair and cryostructuration steps

ES Dragan, MV Dinu, CA Ghiorghita - Gels, 2022 - mdpi.com
Chitosan (CS)-based drug delivery systems (DDSs) are often stabilized by chemical cross-
linking. A much more friendly approach to deliver drugs in a controlled manner is …

Piperine-loaded nanoparticles incorporated into hyaluronic acid/sodium alginate-based membranes for the treatment of inflammatory skin diseases

FAS Politi, SG Carvalho, CF Rodero… - International Journal of …, 2023 - Elsevier
Piperine is an alkaloid mostly found in the fruits of several species of the Piper genus, and its
anti-inflammatory potential is already known. However, its therapeutic applications still need …

[HTML][HTML] Polyelectrolyte complexes (PECs) obtained from chitosan and carboxymethylcellulose: A physicochemical and microstructural study

DCM Ferreira, SO Ferreira, ES de Alvarenga… - Carbohydrate Polymer …, 2022 - Elsevier
Abstract Effects of chitosan (CHS) to carboxymethylcellulose (CMC) mixing ratio (1: 0; 4: 1; 3:
1; 2: 1; 1: 1; 1: 2; 1: 3; 1: 4; 0: 1), temperature (25; 45; 65; 85° C), and pH (3.0; 3.5; 4.0; 4, 5) …

Chitosan surface modification modulates the mucoadhesive, permeation and anti-angiogenic properties of gellan gum/bevacizumab nanoparticles

SG Carvalho, FF Haddad, AM Dos Santos… - International Journal of …, 2024 - Elsevier
Bevacizumab (BVZ) was the first monoclonal antibody approved by the FDA and has shown
an essential advance in the antitumor therapy of colorectal cancer (CRC), however, the …

Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles

AM dos Santos, SG Carvalho, LMB Ferreira… - Colloids and Surfaces A …, 2022 - Elsevier
Judicious design strategies should be considered powerful tools to better control the
properties of chitosan (CS) and tripolyphosphate (TPP) particles. This study focused on …

Multifunctional systems based on nano-in-microparticles as strategies for drug delivery: advances, challenges, and future perspectives

SG Carvalho, AM Dos Santos… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Innovative delivery systems are a promising and attractive approach for drug
targeting in pharmaceutical technology. Among the various drug delivery systems studied …

Multicellular quadruple colorectal cancer spheroids as an in vitro tool for antiangiogenic potential evaluation of nanoparticles

S Carvalho, MJ Silveira, M Domingues… - Advanced …, 2023 - Wiley Online Library
The encapsulation of bevacizumab (BVZ), angiogenesis inhibitor antibody, into nanocarriers
is explored aiming at enhancing its efficacy in colorectal cancer (CRC) treatment while …